Structure of PDB 8kcu Chain C

Receptor sequence
>8kcuC (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
GAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASV
VWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGL
ASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHG
DSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTS
GLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLL
3D structure
PDB8kcu Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs
ChainC
Resolution2.7 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR C Y69 G202 L206 Y68 G201 L205
BS02 CLR C L192 W227 L191 W226
BS03 CLR C Y155 F162 Y154 F161
External links
PDB RCSB:8kcu, PDBe:8kcu, PDBj:8kcu
PDBsum8kcu
PubMed
UniProtQ96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A (Gene Name=APH1A)

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