Structure of PDB 8kcs Chain C

Receptor sequence
>8kcsC (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
GAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASV
VWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGL
ASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHG
DSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTS
GLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLL
3D structure
PDB8kcs Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs
ChainC
Resolution2.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR C Y69 L206 Y68 L205
BS02 CLR C W227 I230 W226 I229
BS03 CLR C Y155 F162 L214 Y154 F161 L213
External links
PDB RCSB:8kcs, PDBe:8kcs, PDBj:8kcs
PDBsum8kcs
PubMed
UniProtQ96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A (Gene Name=APH1A)

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