Structure of PDB 8kco Chain C

Receptor sequence
>8kcoC (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
GAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASV
VWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGL
ASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHG
DSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTS
GLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLL
3D structure
PDB8kco CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560
ChainC
Resolution2.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR C Y69 L206 Y68 L205
BS02 CLR C W227 I230 W226 I229
External links
PDB RCSB:8kco, PDBe:8kco, PDBj:8kco
PDBsum8kco
PubMed
UniProtQ96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A (Gene Name=APH1A)

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