Structure of PDB 8jfz Chain C

Receptor sequence
>8jfzC (length=987) Species: 7797 (Squalus acanthias) [Search protein sequence]
KEVSMDDHKLSLDELHNKYGTDLTRGLTNARAKEILARDGPNSLTPPPTT
PEWIKFCRQLFGGFSILLWIGAILCFLAYGIQAATEDEPANDNLYLGVVL
STVVIVTGCFSYYQEAKSSRIMDSFKNMVPQQALVIRDGEKSTINAEFVV
AGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPEFSSENP
LETRNIAFFSTNCVEGTARGVVVYTGDRTVMGRIATLASGLEVGRTPIAI
EIEHFIHIITGVAVFLGVSFFILSLILGYSWLEAVIFLIGIIVANVPEGL
LATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRM
TVAHMWFDNQIHEADTTENQSGAAFDKTSATWSALSRIAALCNRAVFQAG
QDNVPILKRSVAGDASESALLKCIELCCGSVQGMRDRNPKIVEIPFNSTN
KYQLSIHENEKSSESRYLLVMKGAPERILDRCSTILLNGAEEPLKEDMKE
AFQNAYLELGGLGERVLGFCHFALPEDKYNEGYPFDADEPNFPTTDLCFV
GLMAMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISE
GNETIEDIAARLNIPIGQVNPRDAKACVVHGSDLKDLSTEVLDDILHYHT
EIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGI
SGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPE
ITPFLVFIIGNVPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQP
RNPKTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPMDLIGK
RVRWDDRWISDVEDSFGQQWTYEQRKIVEFTCHTSFFISIVVVQWADLII
CKTRRNSIFQQGMKNKILIFGLFEETALAAFLSYCPGTDVALRMYPLKPS
WWFCAFPYSLIIFLYDEMRRFIIRRSPGGWVEQETYY
3D structure
PDB8jfz Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
ChainC
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C S782 E786 D811 S746 E750 D775
BS02 CLR C E875 S986 E839 S950
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jfz, PDBe:8jfz, PDBj:8jfz
PDBsum8jfz
PubMed37357620
UniProtQ4H132

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