Structure of PDB 8iyx Chain C

Receptor sequence
>8iyxC (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIAD
LLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISL
DRYIKINTTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRD
KHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGYATTARNSFIVLIIFTI
CFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMY
FLMSSNIRKIMCQLLF
3D structure
PDB8iyx Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
ChainC
Resolution3.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S6R C T132 Y135 Y139 I143 F147 L181 G185 T82 Y85 Y89 I93 F97 L122 G126
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iyx, PDBe:8iyx, PDBj:8iyx
PDBsum8iyx
PubMed37733739
UniProtQ9UPC5|GPR34_HUMAN Probable G-protein coupled receptor 34 (Gene Name=GPR34)

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