Structure of PDB 8im2 Chain C

Receptor sequence
>8im2C (length=371) Species: 9606 (Homo sapiens) [Search protein sequence]
DKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSR
EVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDY
IVQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQ
FLPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQ
FHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEY
VDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKT
AKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHN
HQGFGAGNFNSLFKAFEEEQN
3D structure
PDB8im2 Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.
ChainC
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO C H183 H266 E349 H178 H261 E344
BS02 NTD C H183 P239 H266 Q334 F336 F347 E349 F359 N363 F364 L367 H178 P234 H261 Q329 F331 F342 E344 F354 N358 F359 L362
Gene Ontology
Molecular Function
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0009072 aromatic amino acid metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:8im2, PDBe:8im2, PDBj:8im2
PDBsum8im2
PubMed37794595
UniProtP32754|HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase (Gene Name=HPD)

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