Structure of PDB 8ik6 Chain C

Receptor sequence

>8ik6C (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]

GPSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLI
PNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITC
ITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLP
CVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCG
AGLLPEPDCRKVTCENGLGCGFAFCRECKEAYHEGECSVDERAAEQARWE
AKTTKPCPRCHVPVKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHW
FDV

3D structure

PDB

8ik6 Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans.

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	C	C253 H257 C289 C293	C115 H119 C151 C155
BS02	ZN	C	C365 C368 H373 C377	C225 C228 H233 C237
BS03	ZN	C	C446 C449 C457 H461	C284 C287 C295 H299
BS04	ZN	C	C166 C169 C196 C201	C28 C31 C58 C63
BS05	ZN	C	C238 C241 C260 C263	C100 C103 C122 C125
BS06	ZN	C	C332 C337 C352 C360	C194 C199 C214 C220
BS07	ZN	C	C418 R420 C421 C436 C441	C257 R259 C260 C274 C279
BS08	ZN	C	C150 C154 C212 H215	C12 C16 C74 H77

External links

PDB	RCSB:8ik6, PDBe:8ik6, PDBj:8ik6
PDBsum	8ik6
PubMed	39221915
UniProt	O60260\|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)

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