Structure of PDB 8igw Chain C

Receptor sequence
>8igwC (length=585) Species: 768486 (Enterococcus hirae ATCC 9790) [Search protein sequence]
QIGKIIKVSGPLVMAENMSEASIQDMCLVGDLGVIGEIIEMRQDVASIQV
YEETSGIGPGEPVRSTGEALSVELGPGIISQMFDGIQRPLDTFMEVTQSN
FLGRGVQLPALDHEKQWWFEATIEEGTEVSAGDIIGYVDETKIIQHKIMV
PNGIKGTVQKIESGSFTIDDPICVIETEQGLKELTMMQKWPVRRGRPIKQ
KLNPDVPMITGQRVIDTFFPVTKGGAAAVPGPFGAGKTVVQHQIAKWSDV
DLVVYVGCGERGNEMTDVVNEFPELIDPNTGESLMERTVLIANTSNMPVA
AREASIYTGITIAEYFRDMGYDVAIMADSTSRWAEALREMSGRLEEMPGD
EGYPAYLGSRLAEYYERSGRVIALGSDQREGSITAISAVSPSGGDISEPV
TQNTLRVVKVFWGLDSSLAQKRHFPSINWIQSYSLYSTEVGRYMDQILQQ
DWSDMVTEGMRILQEEEQLNEIVRLVGIDSLSDNDRLTLEVAKSIREDYL
QQNAFDDVDTFTSREKQFNMLKVILTFGKEARKALSLGAYFNEIMEGTVA
VRERISRSKYIPEEELAKISSINEEIKETIQLIVS
3D structure
PDB8igw Design of allosteric sites into rotary motor V 1 -ATPase by restoring lost function of pseudo-active sites.
ChainC
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.1: Na(+)-transporting two-sector ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C F234 G235 G237 K238 T239 V240 F425 N504 A505 F506 F233 G234 G236 K237 T238 V239 F424 N503 A504 F505
BS02 ADP C L406 R407 V409 Y434 L405 R406 V408 Y433
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046932 sodium-transporting ATP synthase activity, rotational mechanism
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0046962 sodium-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0042777 proton motive force-driven plasma membrane ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0045259 proton-transporting ATP synthase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8igw, PDBe:8igw, PDBj:8igw
PDBsum8igw
PubMed37414880
UniProtQ08636|NTPA_ENTHA V-type sodium ATPase catalytic subunit A (Gene Name=ntpA)

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