Structure of PDB 8i40 Chain C

Receptor sequence
>8i40C (length=468) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
IGLDKVMSLSSAVQDIKNGATLAVGGFGTGGMPHAIMQEIKKMGVRDLII
YSDGAGVDGYGIGVLFENKQINKMIVSYVGNNKIFARQYLEGDVELEFCP
QGSLAERMRAGGAGIPAFYTPTAVGTVLQTGGQITKYDKNGGVLKESTPR
ETRFFGGRLYCLENAIKTDFSIVKAWKGDRCGNLVFRGTARNFNVPVGQC
GQTVIAEVENLVENGDIDPDEVHLPGVYVDRVVVPERYQTLIEHRTVTRG
EEVRQRIARRAALEFANGMYVNLGIGIPTESSNYIPAGVNVVLQSENGLI
GMGPFPTEDKVDADWINAGKQTISHLAGSALFDSATSFAMIRGGHMDLTM
LGALEVAANGDLANFMIPGKLVKGPGGAMDLVSCGTRVVVTTTHCNKNGD
PKIVERCRLPVTGKHCVCRIITEYAVFDVVDGRLVLKEIAEDTTVDQVKK
LTGVGFDADNVITMPLAP
3D structure
PDB8i40 Crystal structure of ligand complexes of ASCT from Trypanosoma brucei and molecular mechanism in comparison with mammalian SCOT.
ChainC
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.3.5: 3-oxoacid CoA-transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA C I298 I300 E319 A376 L377 N387 A401 N419 K425 I275 I277 E296 A353 L354 N364 A378 N396 K402
Gene Ontology
Molecular Function
GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity
GO:0008410 CoA-transferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0046950 cellular ketone body metabolic process
GO:0046952 ketone body catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Biological Process
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Cellular Component
External links
PDB RCSB:8i40, PDBe:8i40, PDBj:8i40
PDBsum8i40
PubMed
UniProtQ386P1

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