Structure of PDB 8i0z Chain C

Receptor sequence
>8i0zC (length=340) Species: 9913 (Bos taurus) [Search protein sequence]
TRVFKKSSPNGKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFV
TLTVAFRYGREDCDVLGLSFRKDLFIANYQAFPPTRPPTRLQERLLRKLG
QHAHPFFFTIPQNLPSSVTLQPGPEDTGKALGVDFEIRAFVAKSLEEKSH
KRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYY
HGEPLNVNVHVTNNSTKTVKKIKVSVRQYADIVLFSTAQYKVPVAQVEQD
DQVSPSSTFSKVYTITPFLANNREKRGLALDGKLKHEDTNLASSTIVKEG
ANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPH
3D structure
PDB8i0z Structure of beta-arrestin in complex with a phosphopeptide
ChainC
Resolution4.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R8 V9 F10 K11 K12 R26 K108 R2 V3 F4 K5 K6 R20 K98
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0031701 angiotensin receptor binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0002029 desensitization of G protein-coupled receptor signaling pathway
GO:0002031 G protein-coupled receptor internalization
GO:0002092 positive regulation of receptor internalization
GO:0007165 signal transduction
GO:0009968 negative regulation of signal transduction
GO:0015031 protein transport
GO:0031623 receptor internalization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0030139 endocytic vesicle
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0z, PDBe:8i0z, PDBj:8i0z
PDBsum8i0z
PubMed37209686
UniProtP32120|ARRB2_BOVIN Beta-arrestin-2 (Gene Name=ARRB2)

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