Structure of PDB 8i0r Chain C

Receptor sequence
>8i0rC (length=860) Species: 9606 (Homo sapiens) [Search protein sequence]
EVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTTVYEMD
FLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPETEQERGVGIKS
TPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAE
GVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVD
EVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGD
INYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQ
VVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDM
CVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYS
TDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWIS
VARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFN
TTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTG
ELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKN
KITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIW
AFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDEL
IRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYF
VEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGF
ETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREF
MIKTRRRKGL
3D structure
PDB8i0r Molecular Basis for the activation of Human spliceosome
ChainC
Resolution3.0 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C R852 H890 R769 H807
BS02 GTP C H139 G141 K142 T143 C144 G180 K259 D261 R262 S311 Q313 H72 G74 K75 T76 C77 G97 K176 D178 R179 S228 Q230
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0042220 response to cocaine
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0r, PDBe:8i0r, PDBj:8i0r
PDBsum8i0r
PubMed39068178
UniProtQ15029|U5S1_HUMAN 116 kDa U5 small nuclear ribonucleoprotein component (Gene Name=EFTUD2)

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