Structure of PDB 8hzv Chain C

Receptor sequence

>8hzvC (length=477) Species: 9606 (Homo sapiens) [Search protein sequence]

APAERCAHPGADLGAAVHAVGQTLAAGGLVPPDEAGTTARHLVRLAVRYG
NSPFTPLEEARHDLGVDRDAFRRLLALFGQVPELRTAVETGPAGAYWKNT
LLPLEQRGVFDAALARKPVFPYSVGLYPGPTCMFRCHFCVRVTGARYDPS
ALDAGNAMFRSVIDEIPAGNPSAMYFSGGLEPLTNPGLGSLAAHATDHGL
RPTVYTNSFALTERTLERQPGLWGLHAIRTSLYGLNDEEYEQTTGKKAAF
RRVRENLRRFQQLRAERESPINLGFAYIVLPGRASRLLDLVDFIADLNDA
GQGRTIDFVNIREDYSGRDDGKLPQEERAELQEALNAFEERVRERTPGLH
IDYGYALNSLRTGADAELLRIKPATMRPTAHPQVAVQVDLLGDVYLYREA
GFPDLDGATRYIAGRVTPDTSLTEVVRDFVERGGEVAAVDGDEYFMDGFD
QVVTARLNQLERDAADGWEEARGFLRL

3D structure

PDB

8hzv Mechanistic Insights from the Crystal Structure and Computational Analysis of the Radical SAM Deaminase DesII.

Chain

Resolution

2.33002 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	C	C141 F143 C145 C148 R150 G188 N216 Y242	C132 F134 C136 C139 R141 G179 N207 Y233
BS02	SAM	C	F147 G187 G188 L189 E190 Y214 T215 S240 Y242 I287 D323 Y324	F138 G178 G179 L180 E181 Y205 T206 S231 Y233 I278 D314 Y315

External links

PDB	RCSB:8hzv, PDBe:8hzv, PDBj:8hzv
PDBsum	8hzv
PubMed	38943270
UniProt	Q9ZGH1\|DESII_STRVZ dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase (Gene Name=desII)

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