Structure of PDB 8hwg Chain C

Receptor sequence
>8hwgC (length=372) Species: 10244 (Monkeypox virus) [Search protein sequence]
GNKLFNIAQRILDTNSVLLTERGDHIVWINNSWKFNSEEPLITKLILSIR
HQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPFKNGVLDL
VDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNIINDIQPLT
DENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRLLKSAIGD
LFVETGQTILTDVLDKGPNPFIANMHLKRSVFCSELPDFACSGSKKIRSD
NIKKLTEPCVIGRPCFSNKINNRNHATIIIDTNYKPVFDRIDNALMRRIA
VVRFRTHFSQPSGREAAENNDAYDKVKLLDEGLDGKIQNNRYRFAFLYLL
VKWYKKYHIPIMKLYPTPEEIP
3D structure
PDB8hwg Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C P540 R585 C587 F588 P218 R263 C265 F266
BS02 AGS C A506 T507 G508 K509 S510 T511 F630 D652 L655 A184 T185 G186 K187 S188 T189 F308 D330 L333
BS03 AGS C R619 R620 R297 R298
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Cellular Component
GO:0030430 host cell cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8hwg, PDBe:8hwg, PDBj:8hwg
PDBsum8hwg
PubMed38177671
UniProtA0A7H0DN89|PG117_MONPV Uncoating factor OPG117 (Gene Name=OPG117)

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