Structure of PDB 8hwe Chain C

Receptor sequence
>8hweC (length=379) Species: 10244 (Monkeypox virus) [Search protein sequence]
GNKLFNIAQRILDTNSVLLTERGDHIVWINNSWKFNSEEPLITKLILSIR
HQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPFKNGVLDL
VDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNIINDIQPLT
DENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRLLKSAIGD
LFVETGQTILTDVLDKGPNPFIANMHLKRSVFCSELPDFACSGSKKIRSD
NIKKLTEPCVIGRPCFSNKINNRNHATIIIDTNYKPVFDRIDNALMRRIA
VVRFRTHFSQPSGREAAENNDAYDKVKLLDEGLDGKIQNNRYRFAFLYLL
VKWYKKYHIPIMKLYPTPEEIPDFAFYLK
3D structure
PDB8hwe Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus.
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C I464 D467 T505 A506 T507 G508 K509 S510 T511 F630 D652 L655 D656 I142 D145 T183 A184 T185 G186 K187 S188 T189 F308 D330 L333 D334
BS02 ATP C R619 R620 R297 R298
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8hwe, PDBe:8hwe, PDBj:8hwe
PDBsum8hwe
PubMed38177671
UniProtA0A7H0DN89|PG117_MONPV Uncoating factor OPG117 (Gene Name=OPG117)

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