Structure of PDB 8hu6 Chain C

Receptor sequence
>8hu6C (length=619) Species: 9606 (Homo sapiens) [Search protein sequence]
EREFQRVTISGEEKCGVPFTDLLDAAKSVVRALFIREKYMALSLQSFCPT
TRRYLQQLAEKPLEHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRCSEVE
LPYPDLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMK
ELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIV
HVEQGREQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNP
IGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELRLSIYGR
SRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLEN
IFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPE
AWVEEDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHH
LVSAFMLAENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHR
NPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEYSIATQVWKLSSCDMCE
LARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYET
LCQELALITQAVQSEMLET
3D structure
PDB8hu6 The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action.
ChainC
Resolution2.33 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.4.6: AMP deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H418 H420 H687 D764 H172 H174 H441 D518
Gene Ontology
Molecular Function
GO:0003876 AMP deaminase activity
GO:0019239 deaminase activity
Biological Process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0032264 IMP salvage

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8hu6, PDBe:8hu6, PDBj:8hu6
PDBsum8hu6
PubMed36563792
UniProtQ01433|AMPD2_HUMAN AMP deaminase 2 (Gene Name=AMPD2)

[Back to BioLiP]