Structure of PDB 8hmz Chain C

Receptor sequence
>8hmzC (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVEVPAGRVLSARELFAARSRSQKLPQRSHGPKDFLPDGSAAQAERLRR
CREELWQLLAEQRVERLGSLVAAEWRPEEGFVELKSPAGKFWQTMGFSEQ
GRQRLHPEEALYLLECGSIHLFHQDLPLSIQEAYQLLLTDHTVTFLQYQV
FSHLKRLGYVVRRFQPSSVPGQASSPAVVLQHISVLQTTHLPDGGARLLE
KSGGLEIIFDVYQADAVATFRKNNPGKPYARMCISGFDEPVPDLCSLKRL
SYQSGDVPLIFALVDHGDISFYSFRDFTLPQDVGH
3D structure
PDB8hmz Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
ChainC
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C R27 Q31 K32 P40 K41 R73 G96 R20 Q24 K25 P33 K34 R66 G89
BS02 rna C Q35 R36 S37 S105 R462 N464 Q28 R29 S30 S98 R221 N223
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000379 tRNA-type intron splice site recognition and cleavage
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0008033 tRNA processing
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

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Cellular Component
External links
PDB RCSB:8hmz, PDBe:8hmz, PDBj:8hmz
PDBsum8hmz
PubMed37028420
UniProtQ7Z6J9|SEN54_HUMAN tRNA-splicing endonuclease subunit Sen54 (Gene Name=TSEN54)

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