Structure of PDB 8hfv Chain C

Receptor sequence
>8hfvC (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFEESDNNKYWLVKNSWGEEWGMGGYVKMA
KDRRNHCGIASAASYPTV
3D structure
PDB8hfv Crystal structure of CTSL in complex with K777
ChainC
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C D137 H140 D137 H140
BS02 ZN C D71 D114 D71 D114
BS03 ZN C K17 E50 E86 K17 E50 E86
BS04 ZN C E92 E96 E92 E96
BS05 0IW C Q19 C25 E63 G67 G68 L69 A135 M161 D162 H163 W189 Q19 C25 E63 G67 G68 L69 A135 M161 D162 H163 W187
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8hfv, PDBe:8hfv, PDBj:8hfv
PDBsum8hfv
PubMed37990007
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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