Structure of PDB 8hcd Chain C

Receptor sequence
>8hcdC (length=227) Species: 10090 (Mus musculus) [Search protein sequence]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHP
PPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNL
AILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVD
SIAALKALEQASSPRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQ
WKPQALLQWVDEHARPFSTVKPMYGTP
3D structure
PDB8hcd Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids.
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGP C E20 A21 G23 L24 I84 Y129 H195 E16 A17 G19 L20 I80 Y125 H186
BS02 MG C D18 E20 D200 D14 E16 D191
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:8hcd, PDBe:8hcd, PDBj:8hcd
PDBsum8hcd
PubMed37870446
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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