Structure of PDB 8hb2 Chain C

Receptor sequence
>8hb2C (length=254) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
HVNYKVFIYDHIRQIAIPTTNLNSQSSLEDIIDESTSCQSVSTDGSIEID
GLTLIHNFLSESEESKILNMIDTVKWAKSKSGRRKQDYGPKVNFKHKKVK
TDTFVGMPEYADMLLNKMSEYDVKKLGNYQPFEMCNLEYEEVKKSAIEMH
QDDMWIWGNRLISINLINGSVMTLSNDNKSFLCYVHMPHRSLLCMADECR
YDWKHGVLAHHIRGRRIALTMREAAKDFAEGGELYEKYGAELIRLGNIRV
PLSK
3D structure
PDB8hb2 Structural Basis of Nucleic Acid Recognition and 6mA Demethylation by Caenorhabditis elegans NMAD-1A.
ChainC
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.51: DNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN C H184 D186 H150 D152
BS02 AKG C Y173 H184 D186 H239 R250 R256 Y139 H150 D152 H205 R216 R222
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0032451 demethylase activity
GO:0035516 broad specificity oxidative DNA demethylase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0141131 DNA N6-methyladenine demethylase activity
Biological Process
GO:0006260 DNA replication
GO:0010032 meiotic chromosome condensation
GO:0060903 positive regulation of meiosis I
GO:0070988 demethylation
GO:1901046 positive regulation of egg-laying behavior
GO:1905516 positive regulation of fertilization
GO:2000781 positive regulation of double-strand break repair
GO:2001252 positive regulation of chromosome organization
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hb2, PDBe:8hb2, PDBj:8hb2
PDBsum8hb2
PubMed38255759
UniProtQ8MNT9|NMAD1_CAEEL DNA N6-methyl adenine demethylase (Gene Name=nmad-1)

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