Structure of PDB 8h8j Chain C

Receptor sequence
>8h8jC (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
NTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTET
RIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSIS
LVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLG
IQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTD
VGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIR
RALYITSKLSDANCCLDAICYYYMAKEFQEASA
3D structure
PDB8h8j Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35.
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WYB C L80 F163 R164 R240 Y259 S262 L75 F158 R159 R235 Y254 S257
BS02 CLR C S105 T108 L143 P183 S100 T103 L138 P178
BS03 CLR C W52 N61 W141 W47 N56 W136
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
Biological Process
GO:0007010 cytoskeleton organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0035025 positive regulation of Rho protein signal transduction
GO:0070098 chemokine-mediated signaling pathway
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:1904456 negative regulation of neuronal action potential
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h8j, PDBe:8h8j, PDBj:8h8j
PDBsum8h8j
PubMed36543774
UniProtQ9HC97|GPR35_HUMAN G-protein coupled receptor 35 (Gene Name=GPR35)

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