Structure of PDB 8h10 Chain C

Receptor sequence
>8h10C (length=1026) Species: 2901879 (Severe acute respiratory syndrome coronavirus) [Search protein sequence]
TQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHNPVIPFKDGI
YFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPF
FMIFDNAFNCTFEYISDKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSG
FNTLKPIFKLPLGINITNFRAILTAAAAYFVGYLKPTTFMLKYDENGTIT
DAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLC
PFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVCATK
LNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAW
NTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALN
CYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQ
CVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDI
SPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYS
TGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTQKSIVAYTMSL
GADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTEC
ANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGG
FNFSQILPDPLKPTKRSFIEDLLFNKVTLADLICAQKFNGLTVLPPLLTD
DMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLY
ENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLS
SNFGAISSVLNDILSRLCKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAE
IRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTY
VPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITT
DNTFVSGNCDVVIGIINNTVYDPLQP
3D structure
PDB8h10 Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
ChainC
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EIC C I345 A350 Y352 Y356 F361 F364 I272 A277 Y279 Y283 F288 F291
BS02 BLA C V98 R99 I116 I117 N118 R183 F185 K198 V61 R62 I79 I80 N81 R121 F123 K136
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039587 suppression by virus of host tetherin activity
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046598 positive regulation of viral entry into host cell
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0052170 symbiont-mediated suppression of host innate immune response
GO:0061025 membrane fusion
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h10, PDBe:8h10, PDBj:8h10
PDBsum8h10
PubMed37402591
UniProtP59594|SPIKE_SARS Spike glycoprotein (Gene Name=S)

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