Structure of PDB 8gim Chain C

Receptor sequence

>8gimC (length=348) Species: 10090 (Mus musculus) [Search protein sequence]

DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFPLSHFVLS
ATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDI
ILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSF
QGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQL
KKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLE
CLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

PDB

8gim The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS

Chain

Resolution

2.63 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T176 K177 T180
BS02	dna	C	R158 L159 K160 R161 H203 K395	R11 L12 K13 R14 H56 K237
BS03	dna	C	R161 S165 A168 Y200 K372	R14 S18 A21 Y53 K214
BS04	ATP	C	G198 S199 E211 D213 R364 S368 E371 K402 S420 Y421 K424	G51 S52 E64 D66 R206 S210 E213 K244 S262 Y263 K266
BS05	ZN	C	H378 C385 C392	H220 C227 C234
BS06	MG	C	E211 D213 D307	E64 D66 D149
BS07	MG	C	S199 E211 D213	S52 E64 D66

External links

PDB	RCSB:8gim, PDBe:8gim, PDBj:8gim
PDBsum	8gim
PubMed	38740774
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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