Structure of PDB 8gb1 Chain C

Receptor sequence
>8gb1C (length=434) Species: 9606 (Homo sapiens) [Search protein sequence]
MDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGAS
HNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHG
PFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIP
EEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVD
KWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYD
MFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRIST
AIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQ
PTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDAEQLI
RVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDG
3D structure
PDB8gb1 Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding.
ChainC
Resolution2.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YWI C Y155 V156 V378 R451 N452 L453 F454 K455 V557 Y44 V45 V267 R340 N341 L342 F343 K344 V407
BS02 FE C H167 H206 D207 D311 H56 H95 D96 D200
BS03 YWI C K116 D137 R145 K5 D26 R34
External links
PDB RCSB:8gb1, PDBe:8gb1, PDBj:8gb1
PDBsum8gb1
PubMed37233733
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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