Structure of PDB 8g9z Chain C

Receptor sequence
>8g9zC (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
RLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAI
MDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRAVQPKAAGSSLLN
KITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYI
IWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPD
CILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHL
IQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRAS
ASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLH
TPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVS
GYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKER
SKEDVDIEEMALKLDNAL
3D structure
PDB8g9z Structural basis for the tRNA-dependent activation of the terminal complex of selenocysteine synthesis in humans.
ChainC
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C R19 E23 R26 H30 H132 T133 R9 E13 R16 H20 H117 T118
BS02 PLR C A143 T144 G145 Q172 S174 C175 N252 A254 Y255 K284 A128 T129 G130 Q157 S159 C160 N237 A239 Y240 K269
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0098621 O-phosphoseryl-tRNA(Sec) selenium transferase activity
Biological Process
GO:0001514 selenocysteine incorporation
GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g9z, PDBe:8g9z, PDBj:8g9z
PDBsum8g9z
PubMed36929010
UniProtQ9HD40|SPCS_HUMAN O-phosphoseryl-tRNA(Sec) selenium transferase (Gene Name=SEPSECS)

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