Structure of PDB 8g5x Chain C

Receptor sequence
>8g5xC (length=328) Species: 676032 (Francisella cf. tularensis subsp. novicida 3523) [Search protein sequence]
MNRKVALEAVRVTELAALASWSQMGRGDKIAADQAAVDAMRKALNEVDID
GTVVIGEGELDEAPMLYIGEKVGAGGCEVDIALDPLEGTTITSKGGANAL
TVLAMADKGGFLNAPDVYMQKIAVGGINAPKGIVDLDDSVTNNLKRIAEF
KGVHMSALVVCTMDRPRHEHIIKEARECGARVILINDGDVSGVIATATEN
SGIDVYIGTGGAPEGVLAAAALKCLGGQMQARLIFNDEEEIKRAHRLGIT
DLNKKYDIDDLASGDIVFAATGVTDGNMLQGVKRVNSTRRGSYAVTHSVV
MRSTTKTVRHITAEHSFDFKEGIEKFMS
3D structure
PDB8g5x New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.11: fructose-bisphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP C G88 T89 T90 Y118 M163 R165 R167 D187 G188 D189 G211 G88 T89 T90 Y118 M163 R165 R167 D187 G188 D189 G211
BS02 MN C D84 L86 E87 D84 L86 E87
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006071 glycerol metabolic process
GO:0006094 gluconeogenesis
GO:0030388 fructose 1,6-bisphosphate metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:8g5x, PDBe:8g5x, PDBj:8g5x
PDBsum8g5x
PubMed37352301
UniProtQ5NEJ8

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