Structure of PDB 8g5f Chain C

Receptor sequence
>8g5fC (length=343) Species: 10090 (Mus musculus) [Search protein sequence]
TVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTI
DVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNM
TMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAY
TRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVV
MTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTT
VLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTK
RGYAWDGKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNRE
3D structure
PDB8g5f Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
ChainC
Resolution2.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU C F64 R66 F53 R55
BS02 Y4B C I238 Q241 V242 P400 I227 Q230 V231 P325
BS03 PIO C F309 K311 S387 K390 I391 F298 K300 S312 K315 I316
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8g5f, PDBe:8g5f, PDBj:8g5f
PDBsum8g5f
PubMed37730991
UniProtP62812|GBRA1_MOUSE Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=Gabra1)

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