Structure of PDB 8g5d Chain C

Receptor sequence
>8g5dC (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
VPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIG
GVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDL
VSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLI
MGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPN
LILNVAGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFI
GHYLDQKRLKQGLYRHPWDDISYVLPEHM
3D structure
PDB8g5d Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
ChainC
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO C A938 I970 M971 G972 I973 G974 R976 N1024 A1026 A118 I150 M151 G152 I153 G154 R156 N204 A206
BS02 OAA C H900 F935 R1065 H80 F115 R245
BS03 ACO C R1085 H1086 P1087 W1088 R265 H266 P267 W268
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003878 ATP citrate synthase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0006101 citrate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0015936 coenzyme A metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g5d, PDBe:8g5d, PDBj:8g5d
PDBsum8g5d
PubMed37076498
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

[Back to BioLiP]