Structure of PDB 8g4x Chain C

Receptor sequence
>8g4xC (length=343) Species: 10090 (Mus musculus) [Search protein sequence]
TIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTI
DVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNM
TTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAY
TKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVV
MTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTT
VLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTK
RSWAWEGKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRE
3D structure
PDB8g4x Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
ChainC
Resolution2.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU C F89 R91 F53 R55
BS02 PIO C R273 F334 K336 S423 S425 K426 V427 R237 F298 K300 S312 S314 K315 V316
BS03 Y4B C Q266 P436 Q230 P325
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8g4x, PDBe:8g4x, PDBj:8g4x
PDBsum8g4x
PubMed37730991
UniProtP26049|GBRA3_MOUSE Gamma-aminobutyric acid receptor subunit alpha-3 (Gene Name=Gabra3)

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