Structure of PDB 8g4n Chain C

Receptor sequence
>8g4nC (length=346) Species: 10090 (Mus musculus) [Search protein sequence]
DNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDME
YTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVA
HNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGS
YAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGE
YVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG
VTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY
FTKRGYAWDGKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNRE
3D structure
PDB8g4n Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
ChainC
Resolution2.67 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU C F64 R66 F56 R58
BS02 R5R C H101 Y159 S205 T206 Y209 H93 Y151 S197 T198 Y201
BS03 PIO C R248 T305 F309 K311 R312 S387 S389 K390 I391 R240 T297 F301 K303 R304 S315 S317 K318 I319
BS04 Y4B C W245 P400 W237 P328
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g4n, PDBe:8g4n, PDBj:8g4n
PDBsum8g4n
PubMed37730991
UniProtP62812|GBRA1_MOUSE Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=Gabra1)

[Back to BioLiP]