Structure of PDB 8g46 Chain C

Receptor sequence
>8g46C (length=105) Species: 9606 (Homo sapiens) [Search protein sequence]
QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMST
IKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEM
RFAKM
3D structure
PDB8g46 Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YK3 C W374 P375 V380 L385 L387 N433 E438 V439 M442 W22 P23 V28 L33 L35 N81 E86 V87 M90
External links
PDB RCSB:8g46, PDBe:8g46, PDBj:8g46
PDBsum8g46
PubMed36824856
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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