Structure of PDB 8g2p Chain C

Receptor sequence

>8g2pC (length=346) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLGV
LSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISV
NIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAFQGE
TWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKE
FQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLR
TEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL

3D structure

PDB

8g2p Structure of Ternary Complex of cGAS with dsDNA and Bound ATP and GTP

Chain

Resolution

2.521 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T178 K179 T182
BS02	dna	C	R158 L159 K160 R161 H203 K395	R10 L11 K12 R13 H55 K234
BS03	dna	C	R161 S165 A168 N196 Y200 K372	R13 S17 A20 N48 Y52 K211
BS04	ATP	C	G198 S199 E211 D213 R364 S368 E371 K402 S420 Y421 K424	G50 S51 E63 D65 R203 S207 E210 K241 S259 Y260 K263
BS05	GTP	C	T197 M215 S291 P292 N307 I309 K350 R364 S366 S368	T49 M67 S135 P136 N151 I153 K194 R203 S205 S207
BS06	MG	C	E211 D213	E63 D65
BS07	ZN	C	H378 C384 C385 C392	H217 C223 C224 C231

External links

PDB	RCSB:8g2p, PDBe:8g2p, PDBj:8g2p
PDBsum	8g2p
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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