Structure of PDB 8g23 Chain C

Receptor sequence

>8g23C (length=343) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLVL
SATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVD
IILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGETW
RLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQ
ELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTE
KLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

PDB

8g23 The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS

Chain

Resolution

2.71 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T177 K178 T181
BS02	dna	C	R158 L159 K160 R161 K184 H203 K395	R10 L11 K12 R13 K36 H55 K232
BS03	dna	C	R161 S165 N196 Y200 Y201 K372	R13 S17 N48 Y52 Y53 K209
BS04	VWX	C	G198 S199 E211 D213 D307 I309 K350 R364 S366 S368 K402 C419 S420 Y421	G50 S51 E63 D65 D150 I152 K193 R201 S203 S205 K239 C256 S257 Y258
BS05	MG	C	E211 D213	E63 D65
BS06	ZN	C	H378 C385 C392	H215 C222 C229

External links

PDB	RCSB:8g23, PDBe:8g23, PDBj:8g23
PDBsum	8g23
PubMed	38740774
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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