Structure of PDB 8g10 Chain C

Receptor sequence

>8g10C (length=346) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFPLSHFLEGE
VLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEIS
VDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGE
TWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKE
FQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLR
TEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL

3D structure

PDB

8g10 The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS

Chain

Resolution

2.47 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T179 K180 T183
BS02	dna	C	R222 K315	R74 K160
BS03	dna	C	R158 L159 K160 R161 K395	R10 L11 K12 R13 K234
BS04	dna	C	R161 S165 A168 N196 Y200 K372	R13 S17 A20 N48 Y52 K211
BS05	GTP	C	T197 M215 S291 P292 D307 I309 K350 R364 S366 S368	T49 M67 S136 P137 D152 I154 K195 R203 S205 S207
BS06	GTP	C	G198 S199 Q211 N213 R364 S368 E371 K402 S420 Y421	G50 S51 Q63 N65 R203 S207 E210 K241 S259 Y260
BS07	MG	C	Q211 N213	Q63 N65
BS08	ZN	C	H378 C385 C392	H217 C224 C231

External links

PDB	RCSB:8g10, PDBe:8g10, PDBj:8g10
PDBsum	8g10
PubMed	38740774
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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