Structure of PDB 8g0h Chain C

Receptor sequence
>8g0hC (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
ESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWY
HFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEASKKEKDKDSKL
EKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVA
DGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWV
TPKEFREISYLKKLKVKKQDRIFPPET
3D structure
PDB8g0h Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks
ChainC
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C K15 S16 A19 S20 R34 F44 V48 S274 G275 K13 S14 A17 S18 R32 F42 V46 S140 G141
BS02 ZN C C295 C311 C321 C161 C177 C187
BS03 ZN C C21 H53 C56 C19 H51 C54
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8g0h, PDBe:8g0h, PDBj:8g0h
PDBsum8g0h
PubMed38372302
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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