Structure of PDB 8fzm Chain C

Receptor sequence

>8fzmC (length=412) Species: 9606 (Homo sapiens) [Search protein sequence]

SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQ

3D structure

PDB

8fzm Human importin alpha 3 in complex with Bimax2 peptide

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	L99 S100 D102 P105 W137 N141 S144 G145 T150 Q176 W179 N183 D187 N219 W222 R229 W264 Y268 V312 T313 G314 D316 K344 W348 N352 G356 W390 S398	L28 S29 D31 P34 W66 N70 S73 G74 T79 Q105 W108 N112 D116 N148 W151 R158 W193 Y197 V241 T242 G243 D245 K273 W277 N281 G285 W319 S327

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8fzm, PDBe:8fzm, PDBj:8fzm
PDBsum	8fzm
PubMed
UniProt	O00629\|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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