Structure of PDB 8fpv Chain C

Receptor sequence
>8fpvC (length=260) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNK
WWYDKGECGA
3D structure
PDB8fpv The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
ChainC
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CYZ C I481 S729 K730 I89 S214 K215
BS02 GLU C Y450 P478 L479 T480 R485 S654 T655 E705 Y58 P86 L87 T88 R93 S139 T140 E190
BS03 CYZ C K493 P494 M496 S497 L751 S754 L759 D760 K101 P102 M104 S105 L236 S239 L244 D245
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fpv, PDBe:8fpv, PDBj:8fpv
PDBsum8fpv
PubMed38409505
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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