Structure of PDB 8fpl Chain C

Receptor sequence
>8fplC (length=256) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVF
DKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP
CDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWW
YDKGEC
3D structure
PDB8fpl The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
ChainC
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CYZ C I481 S729 G731 I89 S212 G214
BS02 Y4Y C E402 Y450 P478 T480 R485 E705 Y732 E10 Y58 P86 T88 R93 E188 Y215
BS03 CYZ C K493 P494 F495 M496 S497 L751 S754 L759 D760 K101 P102 F103 M104 S105 L234 S237 L242 D243
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fpl, PDBe:8fpl, PDBj:8fpl
PDBsum8fpl
PubMed38409505
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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