Structure of PDB 8fpf Chain C

Receptor sequence

>8fpfC (length=558) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

FSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAIDDMKAGA
FTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHL
LTMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFL
TMGFLISWKLTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRV
LESVSGVRVIRAYVQETNDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKL
LVGASYLIGLGYGAFLVFRNELTLGELVSFNVYLGMMIWPMFAIGELINV
MQRGNASLDRVNETLSYETDVTDPKQPADLKEPGDIVFSHVSFTYPSSTS
DNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGEGSITFSGVP
IQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAEA
HFEKDLHMLPSGLEGGQKQRISIARALMANPEILILDQSLSAVDAKTEAA
IIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLAN
NGWYREQY

3D structure

• PDB: 8fpf Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter
• Chain: C
• Resolution: 3.27 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	C	Y346 N353 G374 G376 K377 T378 T379 Q419 Q500	Y345 N352 G373 G375 K376 T377 T378 Q418 Q488

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8fpf, PDBe:8fpf, PDBj:8fpf
• PDBsum: 8fpf
• PubMed: 37938578
• UniProt: O07550|YHEI_BACSU Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI (Gene Name=yheI)