Structure of PDB 8foi Chain C

Receptor sequence
>8foiC (length=346) Species: 10090 (Mus musculus) [Search protein sequence]
DNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDME
YTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVA
HNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGS
YAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGE
YVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG
VTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY
FTKRGYAWDGKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNRE
3D structure
PDB8foi Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU C F64 R66 F56 R58
BS02 Y4B C Q241 W245 P400 Q233 W237 P328
BS03 PIO C R248 T305 F309 K311 R312 S387 S389 K390 I391 L394 R240 T297 F301 K303 R304 S315 S317 K318 I319 L322
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8foi, PDBe:8foi, PDBj:8foi
PDBsum8foi
PubMed37730991
UniProtP62812|GBRA1_MOUSE Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=Gabra1)

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