Structure of PDB 8foa Chain C

Receptor sequence

>8foaC (length=612) Species: 9606 (Homo sapiens) [Search protein sequence]

ESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRG
AMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVV
NQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSE
EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHG
DHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTST
LYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGR
PYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEA
YMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFH
VLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLG
PFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDY
PMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIA
MMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLG
DRWFLRVEDRQD

3D structure

PDB

8foa Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.

Chain

Resolution

2.66 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GEN	C	M570 L574	M544 L548
BS02	Y01	C	L332 I335 F416 T419 L421 H426 F468 M603 L604	L306 I309 F390 T393 L395 H400 F442 M577 L578
BS03	Y01	C	F456 V459 C463 M466 R470 Q483 K484 F487	F430 V433 C437 M440 R444 Q457 K458 F461
BS04	Y01	C	C494 I501 M528 L530 F531 F534 F537	C468 I475 M502 L504 F505 F508 F511
BS05	ZN	C	H582 H587	H556 H561

Gene Ontology

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0035898	parathyroid hormone secretion
GO:0051592	response to calcium ion
GO:0055074	calcium ion homeostasis
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0098703	calcium ion import across plasma membrane

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0034704	calcium channel complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8foa, PDBe:8foa, PDBj:8foa
PDBsum	8foa
PubMed	37160865
UniProt	Q9H1D0\|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (Gene Name=TRPV6)

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