Structure of PDB 8fo7 Chain C

Receptor sequence
>8fo7C (length=1141) Species: 9606 (Homo sapiens) [Search protein sequence]
AVPYNRMKLMIVGNTGSGKTTLLQQLMKQSATVGIDVKDWPIQIRDKRKR
DLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLF
NIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYH
FVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILS
ERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQ
DPALQLSDLYFVEPKWLCKIMAQILTVKGIISRRDVEKFLSKKRKFPKNY
MTQYFKLIALPIYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG
FWSRLINRLLEISPYMLSGRERALRPNRRYWRQGIYLNWSPEAYCLVGSE
VLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEITLLKK
WALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNK
HTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQ
QDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAA
IIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFG
LLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL
IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVE
KESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFQKNFLLV
GTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVM
WGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYI
AKQNSPVVEVWDKKTEKLCGLIDCVHFLREVTSYSGRVKTLCLQKNTALW
IGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYN
REIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
3D structure
PDB8fo7 Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM
ChainC
Resolution3.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP C S1345 G1346 T1348 T1349 T1368 T1452 H1453 A1490 S17 G18 T20 T21 T32 T116 H117 A154
BS02 4K4 C L1884 L1885 A1904 M1947 A1950 G1953 R1957 D2017 L524 L525 A544 M587 A590 G593 R597 D657
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:8fo7, PDBe:8fo7, PDBj:8fo7
PDBsum8fo7
PubMed38263358
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

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