Structure of PDB 8fny Chain C

Receptor sequence
>8fnyC (length=489) Species: 9606 (Homo sapiens) [Search protein sequence]
FHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDE
VLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDR
DVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHL
EHYIEGKYIKYNSNSGFVRDNIRLTPQAFSHFTFERSGHQLIVVDIQGVG
DLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLS
PRERDAVNQNTKAKTILRGTEEKCHLPRASAVALEVQRLNALDLEKKIGK
SILGKVHLAMVRYHEGGRFCEEWDQESAVFHLEHAANLGELEAIVGLGLM
YSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSG
QNLSPDRCQDWLEALHWYNTALEMQDEPRYMMLAREAEMLFTGGYGLEKD
PQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQME
3D structure
PDB8fny ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin.
ChainC
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.20: [elongation factor 2] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C G141 A142 R144 K170 E229 Y231 I232 Y236 D284 G63 A64 R66 K92 E151 Y153 I154 Y158 D205
BS02 ADP C R114 R116 K151 S153 N154 F155 Y167 Q211 H230 R36 R38 K73 S75 N76 F77 Y89 Q133 H152
BS03 ZN C H260 H312 C314 C318 H181 H233 C235 C239
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0004686 elongation factor-2 kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8fny, PDBe:8fny, PDBj:8fny
PDBsum8fny
PubMed37068230
UniProtO00418|EF2K_HUMAN Eukaryotic elongation factor 2 kinase (Gene Name=EEF2K)

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