Structure of PDB 8fhk Chain C

Receptor sequence

>8fhkC (length=574) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

SVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAIDDMKAGAF
TAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL
TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLT
MGFLISWKLTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVL
ESVSGVRVIRAYVQETNDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLL
VGASYLIGLGYGAFLVFRNELTLGELVSFNVYLGMMIWPMFAIGELINVM
QRGNASLDRVNETLSYETDVTDPKQPADLKEPGDIVFSHVSFTYPSSTSD
NLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGEGSITFSGVPI
QQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAEAH
FEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDQSL
SAVDAKTEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAE
RGTHQELLANNGWYREQYERQQLF

3D structure

• PDB: 8fhk Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
• Chain: C
• Resolution: 2.9 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	C	A474 L475 S476 Q479	A472 L473 S474 Q477
BS02	ATP	C	Y346 S348 N353 T373 G374 G376 K377 T379	Y344 S346 N351 T371 G372 G374 K375 T377

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8fhk, PDBe:8fhk, PDBj:8fhk
• PDBsum: 8fhk
• PubMed: 37938578
• UniProt: O07550|YHEI_BACSU Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI (Gene Name=yheI)