Structure of PDB 8fgw Chain C

Receptor sequence
>8fgwC (length=1342) Species: 9606 (Homo sapiens) [Search protein sequence]
MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSE
INLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQM
SFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE
NLLALGGEDKMITVSNQEGDTIRQTQVRSEPSNMQFFLMKMDDRTSAAES
MISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWYGDGRIMIGFS
CGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKI
QDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKL
PILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHL
AVGMNNRAWFYVLGENAVKKLKDMEYLGTVASICLHSDYAAALFEGKVQL
HLIESEILDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGVVQYF
YIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYE
IPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGAKVILAG
STKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELR
PMLAQNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRR
IGNVGIVMSLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAAL
EMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYVNALAHYEK
GITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAIL
ENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQ
YAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQS
LDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADII
GSEDTTNEDYQSIALYFEGEKRYLQAGKFFLLCGQYSRALKHFLKCPSSE
DNVAIEMAIETVGQAKDELLTNQLIDHLLGENDGMPKDAKYLFRLYMALK
QYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATN
LMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIE
CHRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEAT
TPCPFCKFLLPECELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCDFPAL
YSELKIMLNTESTCPMCSERLNAAQLKKISDCTQYLRTEEEL
3D structure
PDB8fgw Human IFT-A complex structures provide molecular insights into ciliary transport.
ChainC
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1292 C1295 C1314 C1317 C1292 C1295 C1314 C1317
BS02 ZN C C1253 C1267 C1270 C1253 C1267 C1270
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001701 in utero embryonic development
GO:0007224 smoothened signaling pathway
GO:0008406 gonad development
GO:0030030 cell projection organization
GO:0030326 embryonic limb morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0035721 intraciliary retrograde transport
GO:0042471 ear morphogenesis
GO:0043113 receptor clustering
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050877 nervous system process
GO:0055123 digestive system development
GO:0060271 cilium assembly
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061055 myotome development
GO:0065003 protein-containing complex assembly
GO:1903441 protein localization to ciliary membrane
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0030991 intraciliary transport particle A
GO:0031514 motile cilium
GO:0032391 photoreceptor connecting cilium
GO:0097542 ciliary tip
GO:0097730 non-motile cilium

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fgw, PDBe:8fgw, PDBj:8fgw
PDBsum8fgw
PubMed36775821
UniProtQ8NEZ3|WDR19_HUMAN WD repeat-containing protein 19 (Gene Name=WDR19)

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