Structure of PDB 8fgk Chain C

Receptor sequence
>8fgkC (length=414) Species: 9606 (Homo sapiens) [Search protein sequence]
PRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPDVATKDQLF
PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGA
KHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNL
RSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEIC
IQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFK
DLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYN
ILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT
ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFE
YQPDPWNTHVWKLV
3D structure
PDB8fgk Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.
ChainC
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C W414 R419 C420 F589 W592 E597 W683 F709 Y711 W104 R109 C110 F279 W282 E287 W373 F399 Y401
BS02 XVF C Q483 P570 V572 F589 S590 E597 Q173 P260 V262 F279 S280 E287
BS03 ZN C C331 C336 C29 C34
BS04 H4B C S339 R601 V682 W683 S37 R291 V372 W373
BS05 H4B C F696 H697 Q698 E699 F386 H387 Q388 E389
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8fgk, PDBe:8fgk, PDBj:8fgk
PDBsum8fgk
PubMed37433128
UniProtP29475|NOS1_HUMAN Nitric oxide synthase 1 (Gene Name=NOS1)

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