Structure of PDB 8ffw Chain C

Receptor sequence
>8ffwC (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
TIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG
RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSA
NLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKT
LLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQL
TKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGN
IKKLLFHQK
3D structure
PDB8ffw Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
ChainC
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DEX C M604 L608 F623 C638 T739 F740 M86 L90 F105 C120 T221 F222
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8ffw, PDBe:8ffw, PDBj:8ffw
PDBsum8ffw
PubMed37945740
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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