Structure of PDB 8faz Chain C

Receptor sequence
>8fazC (length=314) Species: 9606 (Homo sapiens) [Search protein sequence]
MQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALE
TLQIIRREKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEIC
GAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAT
ACIQHLQLIAEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVY
LLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLAN
NHRLAVILTNQMTVPALGESWGHAATIRLIFHWDRKQRLATLYKSPSQKE
CTVLFQIKPQGFRD
3D structure
PDB8faz Structural insights into BCDX2 complex function in homologous recombination.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C P127 G128 G130 K131 T132 Q133 R168 R322 P103 G104 G106 K107 T108 Q109 R144 R288
BS02 ANP C H307 K328 S329 P330 S331 Q332 K333 E334 H273 K294 S295 P296 S297 Q298 K299 E300
Gene Ontology
Molecular Function
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008821 crossover junction DNA endonuclease activity
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000707 meiotic DNA recombinase assembly
GO:0000722 telomere maintenance via recombination
GO:0000724 double-strand break repair via homologous recombination
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0007062 sister chromatid cohesion
GO:0007066 female meiosis sister chromatid cohesion
GO:0007131 reciprocal meiotic recombination
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0030054 cell junction
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0033065 Rad51C-XRCC3 complex
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8faz, PDBe:8faz, PDBj:8faz
PDBsum8faz
PubMed37344589
UniProtO43502|RA51C_HUMAN DNA repair protein RAD51 homolog 3 (Gene Name=RAD51C)

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