Structure of PDB 8epl Chain C

Receptor sequence
>8eplC (length=948) Species: 9606 (Homo sapiens) [Search protein sequence]
FPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNAR
QLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYN
AKDDEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELN
WTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVKIDLYDVRRR
PWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNV
ASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAF
EQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFTFSVGQ
HNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKA
KQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVD
VSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINS
QEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKG
NRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNF
EESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLIN
RVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQ
ENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQ
GKLLKPAVVGIKIDVNSWIENFTKRNSDVMDCVILDDGGFLLMANHDDYT
NQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAASKQSCITEQ
TQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDT
RLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSG
3D structure
PDB8epl Structures of the R-type human Ca v 2.3 channel reveal conformational crosstalk of the intracellular segments.
ChainC
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C S261 S263 T331 S220 S222 T290
External links
PDB RCSB:8epl, PDBe:8epl, PDBj:8epl
PDBsum8epl
PubMed36446785
UniProtP54289|CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (Gene Name=CACNA2D1)

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