Structure of PDB 8eii Chain C

Receptor sequence
>8eiiC (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]
EDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRF
LELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGT
AAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPK
LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPEGTGRLFFEFYH
LLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVS
AAHRARYFWGNLPGMNRPVIASVPVIRHLFAPLKDYFACE
3D structure
PDB8eii Cryo-EM structure of human DNMT3B homo-tetramer (form II)
ChainC
Resolution3.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C435 C438 C458 C23 C26 C46
BS02 ZN C C478 C481 C500 C503 C66 C69 C88 C91
BS03 ZN C C490 C495 C524 C527 C78 C83 C112 C115
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
Biological Process
GO:0010468 regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:8eii, PDBe:8eii, PDBj:8eii
PDBsum8eii
PubMed37941146
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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