Structure of PDB 8ei5 Chain C

Receptor sequence
>8ei5C (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
RSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRR
RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQIN
PASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLK
DLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGE
SIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE
KELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRI
RLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRL
DLPPYKSYEQLREKLLYAIEETE
3D structure
PDB8ei5 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F651 S654 W657 L668 Q674 F159 S162 W165 L176 Q182
BS02 ZN C T799 T837 T307 T345
BS03 WHL C L668 E669 L176 E177
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei5, PDBe:8ei5, PDBj:8ei5
PDBsum8ei5
PubMed37914719
UniProtO00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (Gene Name=WWP2)

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